Homologous Superfamily

Knottin, scorpion toxin-like superfamily (IPR036574)

Short name: Scorpion_toxin-like_sf

Overlapping entries


Knottins are small proteins characterised by a cystine-knot [PMID: 18025039]. They constitute a large family of structurally related peptides with diverse biological functions, including inhibitors, anti-microbial peptides and toxins [PMID: 15551519]. Their structure is composed of a disulfide-bound fold and contains beta-hairpin with two adjacent disulfides.

The scorpion toxin-like domain is found in a subgroup of metazoan knottins mainly from the arthropoda, which include the antibacterial defensins [PMID: 8380707] and the scorpion alpha-neurotoxins [PMID: 12925796]. The plant sequences include members of the gamma-thionin family, which are plant defensins that have no antifungal activity. Other members are insect alpha-amylase inhibitors, cysteine-rich antifungal proteins and proteins annotated as proteinase inhibitors; those that are characterised belong to MEROPS inhibitor family I18, clan I.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.