Homologous Superfamily

GPCR family 2, extracellular hormone receptor domain superfamily (IPR036445)

Short name: GPCR_2_extracell_dom_sf

Overlapping entries


This domain superfamily is found in the extracellular part of some of the secretin-like (family 2) GPCRs including the corticotropin releasing factor receptor 1; calcitonin receptor; diuretic hormone receptor; glucagon-like peptide 1 receptor; and parathyroid hormone peptide receptor. The N-terminal extracellular domain is the major ligand recognition domain [PMID: 15326300]. This domain structure has a disulfide-rich all-beta fold and contains a beta sandwich of 5 strands.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004930 G protein-coupled receptor activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.