Homologous Superfamily

SMCs flexible hinge superfamily (IPR036277)

Short name: SMC_hinge_sf

Overlapping entries


This entry represents the hinge region superfamily of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that its precise structure is an essential determinant of the specificity of the DNA-protein interaction [PMID: 12411491].

The structure of this hinge region consists of two different alpha+beta subdomains and forms subdomain-swapped dimers.

GO terms

Biological Process

GO:0051276 chromosome organization

Molecular Function

GO:0005524 ATP binding
GO:0005515 protein binding

Cellular Component

GO:0005694 chromosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.