Homologous Superfamily

Tetracyclin repressor-like, C-terminal domain superfamily (IPR036271)

Short name: Tet_transcr_reg_TetR-rel_C_sf

Overlapping entries


This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis [PMID: 7707374]. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. Other members of the TetR family of transcriptional regulators carry this C-terminal domain. These include:

  • QacR from Staphylococcus aureus, a multidrug binding protein that represses transcription of the qacA multidrug transporter gene [PMID: 11739955]
  • Ethr, a repressor from Mycobacterium tuberculosis implicated in ethionamide drug resistance [PMID: 15236969]
  • CprB, a gamma-butyrolactone autoregulator/receptor from Streptomyces coelicolor that acts as a DNA-binding protein [PMID: 14757054]
  • YcdC, a hypothetical transcriptional regulator from Escherichia coli
  • YsiA, YfiR, and YxaF, hypothetical transcriptional regulators from Bacillus subtilis
  • YbiH, a hypothetical transcriptional regulator from Salmonella typhimurium

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.