Homologous Superfamily

Profilin superfamily (IPR036140)

Short name: PFN_sf

Overlapping entries


This entry represents the Profilin superfamily, which are small eukaryotic proteins that have different functions. In plants, they are major allergens present in pollens [PMID: 21458043].

The majority of the Profilin family members binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). They can also in certain circumstance promote actin polymerisation [PMID: 16542844]. However, some Profilin family members, such as Profilin4 from mammals, does not binds to actin and may have functions distinct from regulating actin dynamics [PMID: 19419568]. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain [PMID: 11137023]. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway [PMID: 7945274,PMID: 1651167].

Some Profilins can also bind to polyphosphoinositides such as PIP2 [PMID: 11034907]. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. The N-terminal region is thought to be involved in actin binding.

The Profilin structure has two alpha-helices and five-stranded antiparallel sheet, it has three alpha/beta/alpha layers.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.