Iduronate-2-sulfatase (IPR035874)

Short name: IDS

Overlapping homologous superfamilies

Family relationships



Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate [PMID: 9734337, PMID: 1442257, PMID: 2222422]. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome [PMID: 1303211].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004423 iduronate-2-sulfatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.