SOCS4, SH2 domain (IPR035864)

Short name: SOCS4_SH2

Overlapping homologous superfamilies

Domain relationships

  • SH2 domain (IPR000980)
    • SOCS4, SH2 domain (IPR035864)


SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins [PMID: 17997974]. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [PMID: 15590694].

This entry represents the SH3 domain of SOCS4.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.