SOCS1, SH2 domain (IPR035861)

Short name: SOCS1_SH2

Overlapping homologous superfamilies

Domain relationships

  • SH2 domain (IPR000980)
    • SOCS1, SH2 domain (IPR035861)


This entry represents the SH2 domain of SOCS1.

Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers [PMID: 24069550]. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [PMID: 22423360].

SOCS1 plays a key role in the negative regulation of interferon-gamma signaling and in T cell differentiation [PMID: 11553846, PMID: 12645661, PMID: 21893603].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.