SH3 domain-containing kinase-binding protein 1, second SH3 domain (IPR035771)

Short name: CIN85_SH3_2

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • SH3 domain-containing kinase-binding protein 1, second SH3 domain (IPR035771)


CIN85, also called SH3 domain-containing kinase-binding protein 1 (SH3KBP1), CD2-binding protein 3 (CD2BP3) or Ruk, is an adaptor protein that is involved in the downregulation of receptor tyrosine kinases by facilitating endocytosis through interaction with endophilin-associated ubiquitin ligase Cbl proteins [PMID: 22262777, PMID: 12177062, PMID: 12354621]. It is also important in many other cellular processes including vesicle-mediated transport, cytoskeletal remodelling, apoptosis, cell adhesion and migration, and viral infection, among others [PMID: 20331533]. CIN85 exists as multiple variants from alternative splicing; the main variant contains three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. All of these domains enable CIN85 to bind various protein partners and assemble complexes that have been implicated in many different functions.

This entry represents the second SH3 domain (SH3B) of CIN85. SH3B has been shown to bind Cbl proline-rich peptides and ubiquitin [PMID: 19268472].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.