Ryanodine receptor, SPRY domain 1 (IPR035761)

Short name: SPRY1_RyR

Overlapping homologous superfamilies

Domain relationships

  • SPRY domain (IPR003877)
    • Ryanodine receptor, SPRY domain 1 (IPR035761)


This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR) [PMID: 9204703]. There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3 [PMID: 20961976]. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs [PMID: 19399493]. The first domain may be involved in RyR2 dimerization [PMID: 27332123].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.