SH3RF3, SH3 domain 3 (IPR035612)

Short name: SH3RF3_SH3_3

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • SH3RF3, SH3 domain 3 (IPR035612)


This entry represents the third SH3 domain, located in the middle, of SH3RF3.

SH3RF3 (also known as POSH2) is a scaffold protein with E3 ubiquitin-protein ligase activity [PMID: 20696164]. It was identified in the screen for interacting partners of p21-activated kinase 2 (PAK2). It may play a role in regulating JNK mediated apoptosis in certain conditions [PMID: 17762203]. It also interacts with GTP-loaded Rac1 [PMID: 20696164]. SH3RF3 is highly homologous to SH3RF1; it also contains an N-terminal RING finger domain and four SH3 domains.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.