Domain

Nck1, SH3 domain 1 (IPR035562)

Short name: Nck1_SH3_1

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • Nck1, SH3 domain 1 (IPR035562)

Description

This entry represent the first SH3 domain of Nck1. The first SH3 domain of Nck binds the PxxDY sequence in the CD3e cytoplasmic tail; this binding inhibits phosphorylation by Src kinases, resulting in the downregulation of TCR surface expression [PMID: 18555270].

Nck1 (also called Nck-alpha) plays a crucial role in connecting signaling pathways of tyrosine kinase receptors and important effectors in actin dynamics and cytoskeletal remodeling [PMID: 20971703]. It binds and activates RasGAP, resulting in the downregulation of Ras [PMID: 21664272]. It is also involved in the signaling of endothilin-mediated inhibition of cell migration [PMID: 15187089].

Cytoplasmic proteins Nck are non-enzymatic adaptor proteins composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain [PMID: 21600986]. They regulate actin cytoskeleton dynamics by linking proline-rich effector molecules to protein tyrosine kinases and phosphorylated signaling intermediates [PMID: 12034353]. They function downstream of the PDGFbeta receptor and are involved in Rho GTPase signaling and actin dynamics [PMID: 18765673]. They associate with tyrosine-phosphorylated growth factor receptors or their cellular substrates [PMID: 9344857,PMID: 11240126]. There are two vertebrate Nck proteins, Nck1 and Nck2.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD