Domain

Snake toxin/toxin-like (IPR035076)

Short name: Toxin/TOLIP

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain is predominantly found in venomous neurotoxins and cytotoxins from snakes, but also structurally similar (non-snake) toxin-like proteins (TOLIPs) such as Lymphocyte antigen 6D and Ly6/PLAUR domain-containing protein. Snake toxins are short proteins with a compact, disulphide-rich structure. TOLIPs have similar structural features (abundance of spaced cysteine residues, a high frequency of charge residues, a signal peptide for secretion and a compact structure) but, are not associated with a venom gland or poisonous function. They are endogenous animal proteins that are not restricted to poisonous animals [PMID: 23881252].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam