Pathways & interactions
LARP7, RNA recognition motif 2 (IPR034910)
Short name: LARP7_RRM2
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
This entry represents the RNA recognition motif 2 (RRM2) of La-related protein 7 (LARP7).
LARP7 is an oligopyrimidine-binding protein that binds to the highly conserved 3'-terminal U-rich stretch (3' -UUU-OH) of 7SK RNA. LARP7 is a stable component of the 7SK small nuclear ribonucleoprotein (7SK snRNP). It intimately associates with all the nuclear 7SK and is required for 7SK stability [PMID: 19906723]. LARP7 also acts as a negative transcriptional regulator of cellular and viral polymerase II genes, acting by means of the 7SK snRNP system [PMID: 18483487]. LARP7 plays an essential role in the inhibition of positive transcription elongation factor b (P-TEFb)-dependent transcription, which has been linked to the global control of cell growth and tumorigenesis [PMID: 18249148].
LARP7 contains a La motif (LAM) and an RNA recognition motif (RRM1) at the N-terminal region, which mediates binding to the U-rich 3' terminus of 7SK RNA. LARP7 also carries another putative RRM domain at its C terminus (RRM2).
- cd12542 (RRM2_LARP7)