Domain

Zinc finger C2H2 AKAP95-type (IPR034736)

Short name: ZF_C2H2_AKAP95

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the C2H2 AKAP95-type zinc finger.

A-kinase (or PKA)-anchoring protein AKAP95 is a member of the AKAP-family that binds to regulatory subunits of protein kinase A (PKA) and localizes PKA to various distinct locations and structures within cells. AKAP95 is a zinc-finger protein implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. In addition to anchoring the regulatory subunit (RII) of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), AKAP95 binds chromatin at mitosis. It harbours two zinc fingers, designated ZF1 and ZF2. ZF1 mediates the binding of AKAP95 to DNA. ZF2 is dispensable for chromatin binding; however it may substitute for ZF1 when the latter is rendered non-functional by mutation [PMID: 10697960, PMID: 11964380, PMID: 26683827].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles