E3 ubiquitin-protein ligase RNF168 (IPR034725)

Short name: RNF168

Overlapping homologous superfamilies


Family relationships



RNF168 is a RING-type ubiquitin E3 ligases with roles in the DNA damage response to double-strand breaks (DSBs). It works in concert with another RING-type ubiquitin E3 ligase, RNF8, targeting histones H2A and H2AX. RNF168 amplifies the RNF8-dependent H2A ubiquitination of K-63, promoting the formation ubiquitin conjugates that contribute to the ubiquitin-dependent signals necessary for recruitment of downstream regulators of the DSB response pathway [PMID: 19203579, PMID: 19500350, PMID: 19203578, PMID: 19230794]. Interestingly, RNF168 also catalyses H2A monoubiquitination on K13-15; this seems to be the first step of H2A ubiquitination that drives the DNA damage signaling [PMID: 22980979].

GO terms

Biological Process

GO:0006302 double-strand break repair
GO:0016567 protein ubiquitination

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.