Homologous Superfamily

Arp2/3 complex subunit 2/4 (IPR034666)

Short name: ARPC2/4

Overlapping entries


Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures [PMID: 9600938]. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family protein [PMID: 9889097]. Arp2 and Arp3 are thought to be brought together after activation, forming an actin-like nucleus for actin monomers to bind and create a new actin filament. In the absence of an activating protein, Arp2/3 shows very little nucleation activity. Recent research has focused on the binding and hydrolysis of ATP by Arp2 and Arp3 [PMID: 11752435], and crystal structures of the Arp2/3 complex have been solved [PMID: 15505213].

The human complex consists of Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. This superfamily represents the ARPC2/4 subunits.

GO terms

Biological Process

GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0030041 actin filament polymerization
GO:0030833 regulation of actin filament polymerization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005885 Arp2/3 protein complex
GO:0015629 actin cytoskeleton

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.