SPF45, RNA recognition motif (IPR034653)

Short name: SPF45_RRM

Overlapping homologous superfamilies

Domain relationships


This entry represents the RNA recognition motif (RRM) of SPF45.

SPF45, also termed RNA-binding motif protein 17 (RBM17), is an RNA-binding protein consisting of an unstructured N-terminal region, followed by a G-patch motif and a C-terminal U2AF (U2 auxiliary factor) homology motifs (UHM) that harbours a RNA recognition motif (RRM) and an Arg-Xaa-Phe sequence motif. SPF45 is a bifunctional protein that functions in splicing and DNA repair. It is involved in regulating alternative splicing of the apoptosis regulatory gene FAS (also called CD95). Its UHM binds UHM-ligand motifs (ULMs) present in the 3' splice site-recognizing factors U2AF65, SF1 and SF3b155 [PMID: 17589525]. It binds to the Holliday junction, which is a key DNA intermediate in the homologous-recombination pathway [PMID: 17154718, PMID: 20236180].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.