Kynurenine--oxoglutarate transaminase 3 (IPR034612)

Short name: KAT_III

Overlapping homologous superfamilies

Family relationships



Kynurenine aminotransferases (KATs) catalyze the synthesis of kynurenic acid (KYNA), an endogenous antagonist of the N-methyl-D-aspartate subtype of glutamate receptors and alpha 7-nicotinic acetylcholine receptors, thus playing an important role in protecting neurons from overstimulation by excitatory neurotransmitters. Abnormal KYNA levels in human brains are implicated in the pathophysiology of schizophrenia, Alzheimer's disease, and other neurological disorders [PMID: 10821443, PMID: 17573079]. Four KATs have been reported in mammalian brains [PMID: 19826765].

The biochemical properties of KAT III have been determined in mice. KAT III is able to efficiently catalyze the transamination of kynurenine to KYNA [PMID: 19029248]. It is also active towards a number of other amino acids. As the other KATs, KAT III possesses cysteine S-conjugate beta-lyase activity [PMID: 25231977]. Furthermore, KAT III and glutamine transaminase L are identical enzymes [PMID: 25231977].

GO terms

Biological Process

GO:0006520 cellular amino acid metabolic process
GO:0070189 kynurenine metabolic process

Molecular Function

GO:0036137 kynurenine aminotransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.