ACF, RNA recognition motif 1 (IPR034538)
Short name: ACF_RRM1
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- ACF, RNA recognition motif 1 (IPR034538)
This entry represents the RNA recognition motif 1 (RRM1) of ACF.
ACF (APOBEC-1-stimulating protein, also known as ASP) is an RNA-binding subunit of a core complex that interacts with apoB mRNA to facilitate C to U RNA editing [PMID: 10781591, PMID: 10669759]. It may also act as an apoB mRNA recognition factor and chaperone, and play a key role in cell growth and differentiation. ACF shuttles between the cytoplasm and nucleus [PMID: 20541607].
ACF contains three RNA recognition motifs (RRMs), which display high affinity for an 11 nucleotide AU-rich mooring sequence 3' of the edited cytidine in apoB mRNA. All three RRMs may be required for complementation of editing activity in living cells. RRM2/3 are implicated in ACF interaction with APOBEC-1 [PMID: 20541536].
- cd12486 (RRM1_ACF)