Pathways & interactions
MCM3AP, RNA recognition motif (IPR034265)
Short name: MCM3AP_RRM
Overlapping homologous superfamilies
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- MCM3AP, RNA recognition motif (IPR034265)
This entry represents the RNA recognition motif (RRM) of MCM3-associated protein (MCM3AP, also known as GANP), a nuclear protein with multiple domains, which have different functions. GANP serves as the scaffold of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export [PMID: 22307388]. GANP can act as an RNA export factor that interacts with activation-induced cytidine deaminase (AID) and shepherds it from the cytoplasm to the nucleus, and toward the IgV region loci in B cells [PMID: 24808370].
GANP contains the Sac3-homology domain, a putative RNA recognition motif, the Nup-homology domain, and the C-terminal histone-acetyltransferase (HAT) domain. Its HAT domain has been shown to regulate minichromosome maintenance protein 3 (MCM3) [PMID: 11258703]. An alternatively spliced variant of GANP mRNA has been reported in humans. A shorter isoform of GANP (likely to encode an 80 kDa protein) is associated with MCM3 of the DNA helicase MCM-complex (composed of MCM2-MCM7) and possesses HAT activity [PMID: 23652018].
- cd12443 (RRM_MCM3A_like)