Cytochrome c oxidase subunit 2, C-terminal (IPR034210)

Short name: CcO_II_C

Overlapping homologous superfamilies

Domain relationships


Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear centre (active site) in subunit I [PMID: 11341911, PMID: 17949262].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.