Domain

RNA-binding protein Musashi homologue, RNA recognition motif 2 (IPR034126)

Short name: MSI_RRM2

Domain relationships

Description

This entry represents the RNA recognition motif 2 (RRM2) of Musashi-1, which is a highly conserved RNA binding protein that was initially identified in Drosophila by its ability to regulate sensory organ development and asymmetric cell division [PMID: 22201732]. Mammalian Musashi-1 has multiple functions in normal and abnormal processes by mediating different post-transcriptional processes. It has been implicated in the maintenance of the stem-cell state, differentiation, and tumorigenesis. It translationally regulates the expression of a mammalian numb gene by binding to the 3'-untranslated region of mRNA of Numb, encoding a membrane-associated inhibitor of Notch signaling, and further influences neural development [PMID: 25058468]. Moreover, Musashi-1 represses translation by interacting with the poly(A)-binding protein and competes for binding of the eukaryotic initiation factor-4G (eIF-4G) [PMID: 18490513].

Proteins containing this domain also includes Musashi-2, which has been identified as a regulator of the hematopoietic stem cell (HSC) compartment and of leukemic stem cells after transplantation of cells with loss and gain of function of the gene [PMID: 21613258]. It influences proliferation and differentiation of HSCs and myeloid progenitors, and further modulates normal hematopoiesis and promotes aggressive myeloid leukemia [PMID: 20616797, PMID: 22496868]. Musashi-1 and Musashi-2 contain two conserved N-terminal tandem RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), along with other domains of unknown function

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD