Reprolysin domain, adamalysin-type (IPR034027)

Short name: Reprolysin_adamalysin

Overlapping homologous superfamilies

Domain relationships


This entry includes the reprolysin-like domain found in snake venom metallopeptidases such as adamalysin [PMID: 9521103] and membrane-anchored metalloendopeptidases known as ADAMs (A Disintegrin And Metalloprotease), which are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions [PMID: 10652535, PMID: 9818177, PMID: 7593158]. Peptidase activity depends on the presence of an extended zinc-binding motif known as HEXXHXXGXXH in which the histidines are zinc ligands, the glutamic acid is a catalytic residue and the glycine maintains an important turn. There are a number of proteins in which one or more of these essential residues are not conserved, and these do not have proteolytic activity.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • cd04269 (ZnMc_adamalysin_II_like)