Class I PurE (IPR033747)

Short name: PurE_ClassI

Overlapping homologous superfamilies

Domain relationships


The novo purine biosynthesis proceeds by two divergent paths. In bacteria, yeasts, and plants, 5-aminoimidazole ribonucleotide (AIR) is converted to 4-carboxy-AIR (CAIR) by two enzymes: N5-carboxy-AIR (N5-CAIR) synthetase (PurK) and N5-CAIR mutase (class I PurE). In animals, the conversion of AIR to CAIR requires a single enzyme, AIR carboxylase (class II PurE) [PMID: 7918411]. Class I and class II PurEs are mechanistically related but bind different substrates. In yeast and plants PurE is found in PurK-class I PurE fusion proteins, known as ADE2 [PMID: 8111040, PMID: 9500840], while animal class II PurEs are found in PurC-PurE fusion proteins, also known as ADE2 or PAICS [PMID: 7918410].

This domain represents the class I PurE which is a N5-carboxyaminoimidazole ribonucleotide mutase [PMID: 8117684].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.