Sialidase, Influenza viruses A/B (IPR033654)

Short name: Sialidase_Influenza_A/B

Overlapping homologous superfamilies

Domain relationships



Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates [PMID: 8994884]. Viral neuraminidases, such as this family from Influenza viruses A and B, play a vital role in pathogenesis. Influenza neuraminidase cleaves an alpha-ketosidic linkage between sialic acid and a neighbouring sugar residue [PMID: 23422659, PMID: 10400772]. During budding of virus particles from the infected cell, the sialidase helps to prevent the newly formed viral particles from aggregating. The viral sialidase cleaves terminal sialic acid from glycan structures on the infected cell surface, promoting virus release and the spread of virus to neighbouring cells that are not yet infected. Also, sialidase modifies mucins in the respiratory tract and may improve access of the viral particle to its target cells. Sialidases have a six-bladed beta-propeller fold [PMID: 22649600].

GO terms

Biological Process

GO:0046761 viral budding from plasma membrane

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.