Fatty acyl-CoA reductase, C-terminal (IPR033640)

Short name: FAR_C

Overlapping homologous superfamilies


Domain relationships



This entry represents the C-terminal domain of fatty acyl CoA reductases, a family of SDR-like proteins. SDRs or short-chain dehydrogenases/reductases are Rossmann-fold NAD(P)H-binding proteins. Many proteins with this domain may function as fatty acyl-CoA reductases (FARs), acting on medium and long chain fatty acids, and have been reported to be involved in diverse processes such as the biosynthesis of insect pheromones [PMID: 20542116, PMID: 20534481, PMID: 12871998], plant cuticular wax production [PMID: 16980563], and mammalian wax biosynthesis [PMID: 15220348]. In Arabidopsis thaliana, proteins with this particular architecture have also been identified as the MALE STERILITY 2 (MS2) gene product, which is implicated in male gametogenesis. Mutations in MS2 inhibit the synthesis of exine (sporopollenin), rendering plants unable to reduce pollen wall fatty acids to corresponding alcohols [PMID: 19062129, PMID: 9351246, PMID: 19700560, PMID: 12061894]. The function of this C-terminal domain is unclear.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.