Domain

Class II PurE (IPR033626)

Short name: PurE_classII

Overlapping homologous superfamilies

Domain relationships

Description

The novo purine biosynthesis proceeds by two divergent paths. In bacteria, yeasts, and plants, 5-aminoimidazole ribonucleotide (AIR) is converted to 4-carboxy-AIR (CAIR) by two enzymes: N5-carboxy-AIR (N5-CAIR) synthetase (PurK) and N5-CAIR mutase (class I PurE). In animals, the conversion of AIR to CAIR requires a single enzyme, AIR carboxylase (class II PurE) [PMID: 7918411]. Class I and class II PurEs are mechanistically related but bind different substrates. In yeast and plants PurE is found in PurK-class I PurE fusion proteins, known as ADE2 [PMID: 8111040, PMID: 9500840], while animal class II PurEs are found in PurC-PurE fusion proteins, also known as ADE2 or PAICS [PMID: 7918410].

This entry represents a class II PurE domain found in ADE2 fusion proteins from animals. It is also found in some bacteria, such as Treponema denticola. This spirochete dental pathogen lacks a purK gene and contains a class II purE gene [PMID: 21548610].

GO terms

Biological Process

GO:0006189 'de novo' IMP biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP