Next to BRCA1 gene 1 protein (IPR033513)

Short name: NBR1

Overlapping homologous superfamilies


Family relationships



Selective autophagy is mediated by autophagic cargo receptors such as p62, which facilitates docking of ubiquitinated substrates to the autophagosome [PMID: 21606687]. NBR1 acts as a receptor that cooperates with p62 in the autophagic clearance of ubiquitinated substrates [PMID: 19250911, PMID: 19427866]. NBR1 contains a C-terminal UBA domain that can bind mono- and polyubiquitin [PMID: 19250911].

GO terms

Biological Process

GO:0016236 macroautophagy

Molecular Function

GO:0043130 ubiquitin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.