DNA damage-inducible protein 1 (IPR033322)

Short name: DDI1

Overlapping homologous superfamilies


Family relationships



DNA damage-inducible protein 1 (Ddi1) has been shown to be important in cell cycle control [PMID: 18562697] and for repression of protein secretion [PMID: 21094643]. Ddi1 is required for degradation of Ho endonuclease and F-box protein Ufo1, two proteins involved in cell cycle progression and regulation [PMID: 16478980, PMID: 15964793]. Ddi1 is thought to transfer ubiquitinated substrates to the proteasome for degradation [PMID: 22815701, PMID: 25703377]. The protein contains ubiquitin-like domains [PMID: 25703377] in addition to a peptidase domain [PMID: 18562697].

This entry also includes Mud1 from fission yeasts. It has been shown to to bind to multi-ubiquitin chains [PMID: 11584278].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0043130 ubiquitin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.