MICOS complex subunit MIC26/MIC27, animal (IPR033182)
Short name: MIC26/MIC27_animal
Overlapping homologous superfamilies
- MICOS complex subunit MIC26/MIC27 (IPR019166)
- MICOS complex subunit MIC26/MIC27, animal (IPR033182)
This entry represents MICOS complex subunit MIC26, and its paralogue, MIC27, from animals. The MICOS complex is a central player determining mitochondrial cristae structure and formation of crista junctions [PMID: 25764979].
Human MIC26 (also known as apolipoprotein O, APOO) plays a crucial role in crista junction formation and mitochondrial function [PMID: 25764979] and can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts [PMID: 24743151]. It promotes cholesterol efflux from macrophage cells and can be detected in HDL, LDL and VLDL. It is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL [PMID: 16956892].
Human MIC27 (also known as apolipoprotein O-like, APOOL) is also a subunit of the MICOS complex. It interacts with MIC26 and is involved in the formation of crista junctions [PMID: 25764979].
- PTHR14564 (PTHR14564)