MICOS complex subunit MIC26/MIC27, animal (IPR033182)

Short name: MIC26/MIC27_animal

Overlapping homologous superfamilies


Family relationships


This entry represents MICOS complex subunit MIC26, and its paralogue, MIC27, from animals. The MICOS complex is a central player determining mitochondrial cristae structure and formation of crista junctions [PMID: 25764979].

Human MIC26 (also known as apolipoprotein O, APOO) plays a crucial role in crista junction formation and mitochondrial function [PMID: 25764979] and can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts [PMID: 24743151]. It promotes cholesterol efflux from macrophage cells and can be detected in HDL, LDL and VLDL. It is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL [PMID: 16956892].

Human MIC27 (also known as apolipoprotein O-like, APOOL) is also a subunit of the MICOS complex. It interacts with MIC26 and is involved in the formation of crista junctions [PMID: 25764979].

GO terms

Biological Process

GO:0042407 cristae formation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0061617 MICOS complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.