Domain

Glycosyl hydrolases family 11 (GH11) domain (IPR033123)

Short name: GH11_dom

Overlapping homologous superfamilies

Domain relationships

None.

Description

The microbial degradation of cellulose and xylans requires several types of enzymes such as endoglucanases (EC:3.2.1.4), cellobiohydrolases (EC:3.2.1.91) (exoglucanases), or xylanases (EC:3.2.1.8) [PMID: 2252383, PMID: 1886523]. Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families. One of these families is known as the cellulase family G [PMID: 2806912] or as the glycosyl hydrolases family 11 (GH11) [PMID: 1747104].

The GH11 domain folds into a jelly-roll shape likened to a partially closed right hand. Several anti-parallel beta-strands bend almost 90deg to produce a substrate-binding groove characteristic of the GH11 domain active sites. Two catalytic Glu residues face each other from opposite sides of the groove. The hydrolysis reaction is believed to follow a double- displacement mechanism, with one Glu residue acting as a general acid/base catalyst and the other as a nucleophile.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles