Tenascin-C (IPR033078)

Short name: TNC

Overlapping homologous superfamilies


Family relationships



Tenascin-C (TNC or Tenascin) is an extracellular matrix glycoprotein with multiple functions during development and in the adult [PMID: 16553788]. It is expressed in the developing embryo. In adults expression is constrained to sites with high cell turnover, such as stem cell niches and the central nervous system (CNS), in addition to regions which undergo significant tensile stress, such as tendons, ligaments and smooth muscle fibres. However, most healthy adult tissues exhibit negligible tenascin-C levels [PMID: 25482829]. Its splice variants are highly expressed in cancer tissues [PMID: 25793576]. Tenascin-C interacts with integrins, these interactions can mediate cell proliferation, cell motility, and cell survival [PMID: 26055518].

Tenascins are extracellular matrix glycoproteins that act both as integrin ligands and as modifiers of fibronectin-integrin interactions to regulate cell adhesion, migration, proliferation and differentiation. Tenascins are usually composed of repeated epidermal growth factor (EGF)-like domains, fibronectin-type III (FNIII) domains and a C-terminal fibrinogen related domain (FReD) [PMID: 25482621].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0042127 regulation of cell proliferation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0062023 collagen-containing extracellular matrix

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.