Down syndrome cell adhesion molecule, chordates (IPR033027)

Short name: DSCAM_chordates

Overlapping homologous superfamilies

Family relationships



Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays a role in axon guidance, self-avoidance and synaptic formation [PMID: 19945391, PMID: 18216855, PMID: 18216854, PMID: 19196994, PMID: 18585357]. It is a receptor for netrin, acting independently of and in collaboration with DCC [PMID: 18585357]. DSCAM is one of the largest Immunoglobulin (Ig) superfamily CAMs, containing 10 Ig domains and six fibronectin type III (FN) repeats [PMID: 9426258], and contributes to defects in the central nervous system in Down syndrome patients [PMID: 21270903]. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene [PMID: 19171779]. Drosophila Dscam2 is also alternatively spliced and plays a crucial role in the development of two visual system neurons, monopolar cells L1 and L2 [PMID: 25175881].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0007399 nervous system development

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.