Pathways & interactions
The WD repeat Cdc20/Fizzy family (IPR033010)
Short name: Cdc20/Fizzy
Overlapping homologous superfamilies
- WD40/YVTN repeat-like-containing domain superfamily (IPR015943)
- WD40-repeat-containing domain superfamily (IPR036322)
- The WD repeat Cdc20/Fizzy family (IPR033010)
- Cell division cycle protein 20 homologue (IPR033187)
The anaphase promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that targets mitotic regulators for degradation in exit from mitosis. At the end of mitosis, APC/C is activated by phosphorylation and association with the WD-40 protein Cdc20/Fizzy [PMID: 10799291]. The inhibitory phosphorylation of Cdc20/Fizzy may have a role as a safeguard to keep the cyclosome inactive in early mitosis and under conditions of mitotic checkpoint arrest [PMID: 10799291]. This entry includes Cdc20/Fizzy homologues from fungi, plants and animals.
Three characterised budding yeasts homologues are included in this entry: Cdc20, Cdh1 and Ama1. Cdc20 and Cdh1 have been shown to activate APC/C during mitosis, while Ama1 is a meiosis-specific activator of the APC/C [PMID: 23101628]. The APC/C-Cdh1 is also found involved in the cellular response to DNA damage [PMID: 26650195].
Protein cortex from Drosophila melanogaster which is a female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) required for the completion of meiosis in oocytes, is also included in this entry. Cortex activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis [PMID: 17251266, PMID: 18020708].
- PTHR19918 (PTHR19918)