The WD repeat Cdc20/Fizzy family (IPR033010)

Short name: Cdc20/Fizzy

Overlapping homologous superfamilies

Family relationships


The anaphase promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that targets mitotic regulators for degradation in exit from mitosis. At the end of mitosis, APC/C is activated by phosphorylation and association with the WD-40 protein Cdc20/Fizzy [PMID: 10799291]. The inhibitory phosphorylation of Cdc20/Fizzy may have a role as a safeguard to keep the cyclosome inactive in early mitosis and under conditions of mitotic checkpoint arrest [PMID: 10799291]. This entry includes Cdc20/Fizzy homologues from fungi, plants and animals.

Three characterised budding yeasts homologues are included in this entry: Cdc20, Cdh1 and Ama1. Cdc20 and Cdh1 have been shown to activate APC/C during mitosis, while Ama1 is a meiosis-specific activator of the APC/C [PMID: 23101628]. The APC/C-Cdh1 is also found involved in the cellular response to DNA damage [PMID: 26650195].

Protein cortex from Drosophila melanogaster which is a female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) required for the completion of meiosis in oocytes, is also included in this entry. Cortex activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis [PMID: 17251266, PMID: 18020708].

GO terms

Biological Process

GO:1904668 positive regulation of ubiquitin protein ligase activity

Molecular Function

GO:0010997 anaphase-promoting complex binding
GO:0097027 ubiquitin-protein transferase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.