Contactin-6 (IPR033009)

Short name: Contactin-6

Overlapping homologous superfamilies

Family relationships



Contactin-6 (CNTN6/NB-3) binds Notch and and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells [PMID: 15082708, PMID: 25074942]. CNTN6/NB-3 is also involved in synapse formation [PMID: 19672956, PMID: 20176085] and in the normal projection and terminal branching of developing corticospinal tract axons [PMID: 21935948].

Contactins are cell adhesion molecules that belong to the immunoglobulin superfamily and are involved in neural development [PMID: 25300137]. They usually consist of six N-terminal Ig domains, four fibronectin type III domains, and a C-terminal glycophosphatidylinositol (GPI)-anchor to the extracellular part of the cell membrane [PMID: 21846565].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0007399 nervous system development
GO:0022008 neurogenesis
GO:0030182 neuron differentiation

Molecular Function

GO:0005112 Notch binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.