Protein atonal homologue 8 (IPR032660)

Short name: ATOH8

Overlapping homologous superfamilies


Family relationships



Protein atonal homologue 8 (ATOH8, also known as Math6) is a basic helix loop helix (bHLH) transcription factor that has been implicated in development of various tissues, such as pancreas, retina and skeletal muscle, during early development [PMID: 18560595, PMID: 20532172, PMID: 24186058, PMID: 21857980]. Interestingly, hepatic ATOH8 mRNA levels were up-regulated in mice chronically fed a high iron diet and down-regulated in those fed an iron-deficient diet [PMID: 18539898]. ATOH8 has also been found to regulate iron hormone hepcidin (HAMP) transcription and cellular pSMAD1,5,8 levels [PMID: 24236640]. ATOH8 can also serve as a marker in human muscle fibre regeneration [PMID: 25514850].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0030154 cell differentiation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.