Pathways & interactions
Oligodendrocyte transcription factor 3 (IPR032659)
Short name: Olig3
Overlapping homologous superfamilies
- Helix-loop-helix DNA-binding domain superfamily (IPR036638)
Oligodendrocyte transcription factor 3 (Olig3) is a basic-helix-loop-helix (bHLH) transcription factor that coordinatess the specification of dorsal neurons in the spinal cord [PMID: 15769945, PMID: 15731351]. It marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei [PMID: 19088088].
The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].
- PTHR19290:SF96 (PTHR19290:SF96)