Oligodendrocyte transcription factor 3 (IPR032659)

Short name: Olig3

Overlapping homologous superfamilies

Family relationships



Oligodendrocyte transcription factor 3 (Olig3) is a basic-helix-loop-helix (bHLH) transcription factor that coordinatess the specification of dorsal neurons in the spinal cord [PMID: 15769945, PMID: 15731351]. It marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei [PMID: 19088088].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0021520 spinal cord motor neuron cell fate specification

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.