Domain

Recq-mediated genome instability protein 1, C-terminal OB-fold domain (IPR032199)

Short name: RMI1_C

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The dissolvasome is a protein complex that consists of BLM, a RecQ helicase that is product of the gene mutated in Bloom syndrome, topoisomerase IIIalpha (Top3alpha) and the RMI (RecQ-mediated genome instability) subcomplex, comprised of RMI1 and RMI2. The dissolvasome acts on double Holliday junction intermediates in homologous recombination, creating non-crossover products in a process termed 'dissolution' [PMID: 14685245, PMID: 16537486].

This entry represents the C-terminal oligo-nucleotide binding domain of Recq-mediated genome instability protein RMI1. This domain interacts with RMI2-OB folds to make up the RMI core complex. The RMI core interface is crucial for dissolvasome assembly and may have additional cellular roles as a docking hub for other proteins [PMID: 18923082, PMID: 20826341].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0000166 nucleotide binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam