Family

OPI10 family (IPR031318)

Short name: OPI10

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

OPI10 family members include protein Hikeshi from vertebrates and protein Opi10 from yeasts.

Hikeshi protein acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress; it acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus [PMID: 22541429].

Budding yeast Opi10 is a repressor of the phospholipid biosynthetic genes and specifically binds PA in the endoplasmic reticulum [PMID: 16582425].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER