Cellular retinoic acid-binding protein 2 (IPR031281)

Short name: CRABP2

Overlapping homologous superfamilies

Family relationships


The lipid-binding protein (LBP) family can be divided divided in four subfamiles. Subfamily I comprises proteins specific for vitamin A derivatives, and can be subdivided into the cellular retinoic acid-binding proteins (CRABP-I and II) and the cellular retinol-binding proteins (CRBP-I, II, III, and IV) [PMID: 15234551].

This entry represents retinoic acid-binding protein 2 (CRABP-II). Both CRABP I and II are present in the cytoplasm, but CRABP-II is also found in the nucleus. CRABP-II transports retinoic acid (RA) to the nucleus, regulating the activation of nuclear RA receptors [PMID: 10490651, PMID: 10817966, PMID: 20140749].

GO terms

Biological Process

GO:0048385 regulation of retinoic acid receptor signaling pathway

Molecular Function

GO:0001972 retinoic acid binding

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.