Intracellular lipid binding protein (IPR031259)

Short name: ILBP

Overlapping homologous superfamilies

Family relationships


Fatty acid binding proteins (FABPs) and cellular retinoic-acid-binding proteins (CRBPs) are part of the intracellular-lipid-binding proteins (iLBPs) family [PMID: 12479570].

The primary role of all the FABP members is regulation of fatty acid uptake and intracellular transport [PMID: 16424607]. To date, nine FABPs have been identified in mammals, each showing specific tissue distribution patterns and ligand preference. All FABP members have a similar beta-barrel structure; fatty acid ligands are accommodated in the central cavity of the beta-barrel, which dramatically increases their solubility in the aqueous cytoplasm, facilitating their movement to target sites [PMID: 16424607, PMID: 9082452].

Retinoic-acid-binding proteins (CRBPs) are specific for vitamin A derivatives and can be classified into the cellular retinoic acid-binding proteins (CRABP-I and II) and the cellular retinol-binding proteins (CRBP-I, II, III, and IV) [PMID: 15234551].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008289 lipid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.