ATPase family AAA domain-containing protein 2 (IPR031252)

Short name: ANCCA

Overlapping homologous superfamilies


Family relationships



ATPase family AAA domain-containing protein 2, also known as ANCCA, is a transcriptional coactivator for estrogen-bound estrogen receptor (ER) alpha and androgen receptor [PMID: 17998543, PMID: 19318566]. It is required for coregulator occupancy and chromatin modification [PMID: 17998543]. ANCCA is also required for recruiting specific E2Fs to their targets and for the assembly of the HCF-MLL hKMT complex, a complex that regulates cell cycle progression [PMID: 20855524]. Overexpression of ANCCA has been linked to various cancers [PMID: 20124470, PMID: 24708861, PMID: 23775406].

GO terms

Biological Process

GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0016887 ATPase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.