Family

Syndecan-3 (IPR031194)

Short name: Syndecan-3

Overlapping homologous superfamilies

None.

Family relationships

  • Syndecan (IPR001050)
    • Syndecan-3 (IPR031194)

Description

Four members of the syndecan family of transmembrane heparan sulfate proteoglycans are expressed in mammals, Sdc1-4 [PMID: 1335744, PMID: 21062643].

Syndecans-3 has a tissue-dependent role in inflammation. In the joint it is selectively pro-inflammatory, whereas in skin and cremaster it is anti-inflammatory [PMID: 25015005].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER