ELL/occludin family (IPR031176)

Short name: ELL/occludin

Overlapping homologous superfamilies


Family relationships


This entry represents the ELL/occludin family. Occludin is found in the tight junction and may play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier [PMID: 19114660]. ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF [PMID: 17150956].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.