High mobility group protein HMGB2 (IPR031075)

Short name: HMGB2

Overlapping homologous superfamilies


Family relationships



This entry represents HMGB2 (also known as HMG-2). It is involved in V(D)J recombination by acting as a cofactor of the RAG complex [PMID: 9184213]. It functions as a modulator of neurogenesis in young adult mice through regulation of neural stem and progenitor cell proliferation [PMID: 24391977]. It has a role in germ cell differentiation [PMID: 11262228] and erythroid [PMID: 19965638] and mesenchymal stem cell differentiation [PMID: 21890638]. Overexpression of HMGB2 has been linked to several malignant cancers [PMID: 23255232, PMID: 25327479].

The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [PMID: 25281808].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.