PAN2-PAN3 deadenylation complex subunit PAN3 (IPR030844)

Short name: PAN3

Overlapping homologous superfamilies

Family relationships



Pan3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of the two eukaryotic poly(A) nuclease complexes (Ccr4-Caf1 and Pan2-Pan3) involved in mRNA decay [PMID: 16284618, PMID: 8550599]. It contains a PABP-interacting motif 2 (PAM2) that binds to the C-terminal domain of polyA binding proteins (PABPs) [PMID: 17595167]. It recruits the Pan2-Pan3 complex to mRNA through the Pan3-PABP interaction [PMID: 24880343].

Regulation of mRNA decay rates in eukaryotic cells affects gene expression [PMID: 11283721]. The Pan2-Pan3 complex shortens cytoplasmic mRNA 3' polyA tails to regulate mRNA stability [PMID: 24872509]. In the complex Pan2 provides the catalytic activity, whereas Pan3 mediates Pan2 recruitment to mRNA targets [PMID: 24880343].

GO terms

Biological Process

GO:0006397 mRNA processing
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening

Molecular Function

GO:0003723 RNA binding

Cellular Component

GO:0031251 PAN complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.