Ras-specific guanine nucleotide-releasing factor RalGPS1/2 (IPR030708)

Short name: RalGPS1/2

Overlapping homologous superfamilies

Family relationships


This entry includes RalGPS1 (also known as RalGEF2) and RalGPS2. RalGPS1 and RalGPS2 are guanine nucleotide exchange factors for Ral (RalA and RalB), a ubiquitously expressed Ras-like small GTPase [PMID: 10889189, PMID: 20025911]. The PH-PxxP domain of RalGPS2 acts as a negative regulator for RalA GTPase activation and promotes PC12 cells differentiation [PMID: 20025911].

GO terms

Biological Process

GO:0032485 regulation of Ral protein signal transduction

Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.