Dihydropyrimidinase-related protein 1 (IPR030624)

Short name: CRMP1

Overlapping homologous superfamilies

Family relationships


The Dihydropyrimidinase Related Protein (DRP) family, also known as collapsin response mediator proteins (CRMPs), consists of five members, DRP1-5. Members of this family have been proposed to be part of the semaphorins signal transduction pathway involved in neurite outgrowth, and neuronal differentiation and death [PMID: 11085871, PMID: 23443259]. They are cytosolic proteins highly expressed throughout brain development [PMID: 14514985].

Dihydropyrimidinase-related protein 1, also known as collapsin response mediator protein 1 (CRMP1) or ULIP3, interacts with semaphorin3A in the dendritic and synaptic development of the cortical neurons [PMID: 18003833, PMID: 25358863]. Both CRMP1 and CRMP2 contribute to cytoskeletal reorganisation in the axonal pathfinding process [PMID: 22378692].

GO terms

Biological Process

GO:0007411 axon guidance
GO:0000226 microtubule cytoskeleton organization
GO:0007399 nervous system development

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.