Dihydropyrimidinase-related protein 4 (IPR030612)
Short name: DRP4
Overlapping homologous superfamilies
- Metal-dependent hydrolase, composite domain superfamily (IPR011059)
- Metal-dependent hydrolase (IPR032466)
- Hydantoinase/dihydropyrimidinase (IPR011778)
- Dihydropyrimidinase-related protein 4 (IPR030612)
The Dihydropyrimidinase Related Protein (DRP) family, also known as collapsin response mediator proteins (CRMPs), consists of five members, DRP1-5. Members of this family have been proposed to be part of the semaphorins signal transduction pathway involved in neurite outgrowth, and neuronal differentiation and death [PMID: 11085871, PMID: 23443259]. They are cytosolic proteins highly expressed throughout brain development [PMID: 14514985].
This entry represents dihydropyrimidinase-related protein 4 (DRP4), also known as CRMP3 or ULIP4. DRP4/CRMP3 is required for hippocampal dendritic organisation, plasticity [PMID: 17785607], and growth, which is linked to CRMP3-mediated Ca(2+) influx [PMID: 23868973]. DRP4/CRMP3 has histone H4 deacetylase (HDAC) activity. Nuclear DRP4/CRMP3 modulates the expression of the transcription factor E2F1, serving as a potential mechanism for CRMP3-induced neuronal death [PMID: 23443259].
- PTHR11647:SF55 (PTHR11647:SF55)