Dihydropyrimidinase-related protein 4 (IPR030612)

Short name: DRP4

Overlapping homologous superfamilies

Family relationships


The Dihydropyrimidinase Related Protein (DRP) family, also known as collapsin response mediator proteins (CRMPs), consists of five members, DRP1-5. Members of this family have been proposed to be part of the semaphorins signal transduction pathway involved in neurite outgrowth, and neuronal differentiation and death [PMID: 11085871, PMID: 23443259]. They are cytosolic proteins highly expressed throughout brain development [PMID: 14514985].

This entry represents dihydropyrimidinase-related protein 4 (DRP4), also known as CRMP3 or ULIP4. DRP4/CRMP3 is required for hippocampal dendritic organisation, plasticity [PMID: 17785607], and growth, which is linked to CRMP3-mediated Ca(2+) influx [PMID: 23868973]. DRP4/CRMP3 has histone H4 deacetylase (HDAC) activity. Nuclear DRP4/CRMP3 modulates the expression of the transcription factor E2F1, serving as a potential mechanism for CRMP3-induced neuronal death [PMID: 23443259].

GO terms

Biological Process

GO:0070997 neuron death
GO:0097485 neuron projection guidance

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.